Dr. med. Dirk Manski



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Benign Prostatic Hyperplasia (BPH): Signs and Symptoms


Review literature: (Burnett und Wein, 2006) (DGU-Guideline: diagnostic work-up, 2009) (DGU-Guideline: treatment, 2009) (EAU-Guideline: Oelke et al, 2010)

Micturition Symptoms of Benign Prostatic Hyperplasia (BPH)

Irritative Micturition Symptoms:


Causes of irritative micturition symptoms:

Obstructive Micturition Symptoms:

Causes of obstructive micturition symptoms:

Prostatic hyperplasia leads to the compression and narrowing of the prostatic urethra and to obstructive micturition symptoms.

Overflow Urinary Incontinence:

BPH may cause different types of urinary incontinence: overflow urinary incontinence due to chronic urinary retention or urge incontinence due to detrusor instability. The surgical treatment of BPH includes the risk of developing stress urinary incontinence, if the urinary sphincter is damaged.

Erectile Dysfunction:

Erectile dysfunction may be caused by BPH itself or by different kind of treatments (e.g. open prostatectomy, 5alpha-reductase inhibitors). The treatment of BPH, however, may also improve sexual function, particularly alpha blocker such as doxazosin are advantageous.

Complications of Benign Prostatic Hyperplasia

Urinary retention:

Risk factors for the development of urinary retention are prostatitis, bladder overdistension, high fluid intake, alcohol, sexual activity, debility, drugs (e.g. sympathomimetics, anticholinergics), bed rest, surgery and general anesthesia. The prognosis for the recovery of spontaneous voiding after urinary retention is better, if above mentioned risk factors are present and the patient does not suffer from obstructive micturition symptoms. In indolent patients, urinary retention may present as a lower abdominal tumor [fig. abdominal tumor due to urinary retention].

fig. acute urinary retention caused by benign prostatic hyperplasia (BPH) presenting as an abdominal tumor  

fig. acute urinary retention in benign prostatic hyperplasia (BPH): the massive distended bladder appears as an abdominal tumor. The patient suffered from overflow urinary incontinence, but did not report any abdominal pain. With kind permission of Dr. R. Gumpinger, Kempten.

Postrenal kidney failure:

BPH may lead to vesicoureteral reflux, hydronephrosis and postrenal kidney failure, symptoms of uremia may be lethargy, decreased mental acuity, coma, nausea, vomiting, bone pain, itch, shortness of breath and seizures.

Further complications of Benign Prostatic Hyperplasia (BPH):

Quantification of LUTS with the International Prostate Symptoms Score (IPSS)

The validated International Prostate Symptoms Score (IPSS) consists of 8 questions and should be used for the quantification of the BPH symptoms. This enables the monitoring of treatment success. The IPSS, however, has no diagnostic value, since other diseases like infections, neurogenic bladder disorders or tumors may also cause high IPSS scores.

Evaluation of the IPSS:

Seven questions deal with symptoms like incomplete bladder emptying, frequency, intermittency, urgency, weak stream, straining and nocturia. The score of each question (from 1 to 5) sums up for maximum of 35 points. The severity of BPH symptoms may be classified into mild (0 to 7 points), moderate (8 to 19 points) and severe (20 to 35 points). The 8th question deals with the quality of life (score from 1 to 6).

Residual urine:

Over the past month, how often have you had a sensation of not emptying your bladder completely after you finish urinating?

Frequency:

Over the past month, how often have you had to urinate again less than two hours after you finished urinating? (0–5 points, see classification residual urine)

Intermittency:

Over the past month, how often have you found you stopped and started again several times when you urinated? (0–5 points, see classification residual urine).

Urgency:

Over the last month, how difficult have you found it to postpone urination? (0–5 points, see classification residual urine)

Weak stream:

Over the past month, how often have you had a weak urinary stream? (0–5 points, see classification residual urine)

Straining during urination:

Over the past month, how often have you had to push or strain to begin urination? (0–5 points, see classification residual urine)

Nocturia:

Over the past month, many times did you most typically get up to urinate from the time you went to bed until the time you got up in the morning? (0–5 points depending on the times of nocturia)

Quality of life:

If you were to spend the rest of your life with your urinary condition the way it is now, how would you feel about that? [1–5 points: from delighted (0), pleased (1), mostly satisfied (2), mixed – about equally satisfied and dissatisfied (3), unhappy (4) and terrible (5)]







Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



References



Burnett und Wein 2006 BURNETT, A. L. ; WEIN, A. J.:
Benign prostatic hyperplasia in primary care: what you need to know.
In: J Urol
175 (2006), Nr. 3 Pt 2, S. S19–24

DGU-Guidelines: diagnostic work-up
Leitlinien der Deutschen Urologen zur Diagnostik des benignen Prostatasyndroms (BPS).
In: Urologe A
48 (2009), S. 1356–60, 1362–4


DGU-Guidelines: treatment
Leitlinien der Deutschen Urologen zur Therapie des benignen Prostatasyndroms (BPS).
In: Urologe A
48 (2009), S. 1503–1516


Oelke, M.; Bachmann, A.; Descazeaud, A. & Emberton, M.
Guidelines on conservative treatment of non-neurogenic male LUTS
www.uroweb.org, 2010.


  Deutsche Version: Symptome der benignen Prostatahyperplasie