Dr. med. Dirk Manski

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Alpha-Blocker (2/5): Doxazosin

Review Literatur: (Chapple, 2004).

General Pharmacology of Doxazosin

Please see section general pharmacology of alpha-blocker.

Mechanism of Action of Doxazosin

Doxazosin is a non-selective alpha1-blocker with a long elimination half-life.

Indications for Doxazosin

Pharmacokinetics of Doxazosin

Doxazosin: Mechanism of Action

Postsynaptic alpha1-blockade leads to:

Side Effects of Doxazosin

Contraindications of Doxazosin

Urological Contraindications:

Conservative treatment of BPH is not indicated, if surgical treatment is imperative: chronic urinary retention with renal failure, recurrent hematuria due to prostatic enlargement, recurrent infections and bladder stones.

Cardiac Contraindications:

Hypotension, mechanical heart failure (valvular, pulmonary embolism, pericarditis), congestive heart failure.

Other contraindications:

Doxazosin should be paused perioperatively for cataract surgery to prevent an intraoperative floppy iris syndrome.

Dosage of Doxazosin

The treatment of doxazosin should be started with a low dosage, such as 1 mg 1-0-0. The dosage can be increased each week to 2–4–8 mg 1-0-0, depending on treatment effect, side effects and blood pressure.

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Chapple 2004 CHAPPLE, C. R.:
Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician.
In: BJU Int
94 (2004), Nr. 5, S. 738–44

  Deutsche Version: Doxazosin