Dr. med. Dirk Manski

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Alpha Blocker: General Side Effects and Contraindications

The adrenergic receptors transmit the effects of the sympathetic nervous system and, thus of adrenaline and noradrenaline. The different α1, α2, β1$, β2 and β3 receptors mediate entirely different effects depending on the organ. Alpha blockers used in urology are antagonists at the α1 receptor. Review Literatur: (Chapple, 2004).

Alpha Blocker: Pharmacology and Side Effects

Postsynaptic α1 blocking leads to:

Indications of Alpha Blocker

Side Effects of Alpha Blocker

Contraindications of Alpha Blocker

Urological Contraindications:

Conservative treatment of BPH is not indicated if surgical treatment is imperative: chronic urinary retention with renal failure, recurrent hematuria due to prostatic enlargement, recurrent urinary tract infections or bladder stones.

Cardiac Contraindications:

Hypotension, mechanical heart failure (valvular, pulmonary embolism, pericarditis), congestive heart failure.

Other contraindications:

Severe liver insufficiency. Pause alpha blockers before cataract surgery to prevent an intraoperative floppy iris syndrome.

Drug interactions

Do not combine two alpha blockers for better treatment effect.

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Chapple 2004 CHAPPLE, C. R.: Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician.
In: BJU Int
94 (2004), Nr. 5, S. 738–44

C. de Mey, “alpha(1)-blockers for BPH: are there differences?,” Eur Urol, vol. 36 Suppl 3, pp. 52–63, 1999.

  Deutsche Version: Alpha Blocker