Dr. med. Dirk Manski

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Anticholinergics (1/9)

Review literature Anticholinergic drugs: (Ouslander, 2004) (Yoshimura and Chancellor, 2002).

Mechanism of Action of Anticholinergic Drugs

Anticholinergic drugs act as antagonists on cholinergic (=muscarinic) receptors, this leads to smooth muscle relaxation of the bladder [see section receptors of the urinary bladder].

Indications for Anticholinergics:

Side Effects of Anticholinergics

Patients often do not complete the course of anticholinergic treatment due to the high rate of unwanted side effects:

GI tract:

Drug Interactions of Anticholinergics

Increased anticholinergic effect with antiparkinson drugs, antihistamines, antipsychotics, tricyclic antidepressants. Amplification of the tachycardic effect of sympathomimetic drugs. Anticholinergics mitigate the effects of gastrointestinal prokinetics.

Contraindications of Anticholinergics

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Ouslander 2004 OUSLANDER, J. G.: Management of overactive bladder.
In: N Engl J Med
350 (2004), Nr. 8, S. 786–99

Yoshimura und Chancellor 2002 YOSHIMURA, N. ; CHANCELLOR, M. B.: Current and future pharmacological treatment for overactive bladder.
In: J Urol
168 (2002), Nr. 5, S. 1897–913

  Deutsche Version: Anticholinergika