Dr. med. Dirk Manski

 You are here: Urology Textbook > Drugs in Urology > Alpha blocker > Tamsulosin

Alpha Blocker Tamsulosin: Side Effects and Dosage

Mechanism of Action of Tamsulosin

Tamsulosin is a selective α1A and α1D blocker with a long half-life and favorable cardiovascular side effects. Please see section general pharmacology of alpha blocker.

figure structural formula of tamsulosin
Structural formula of tamsulosin

Indications for Tamsulosin

Pharmacokinetics of Tamsulosin

Side Effects of Tamsulosin

Decreased side effect profile since tamsulosin is a selective α1A and α1D blocker.

Contraindications of Tamsulosin

Urological Contraindications:

Conservative treatment of BPH with tamsulosin is not indicated, if surgical treatment is imperative: chronic urinary retention with renal failure, recurrent hematuria due to prostatic enlargement, recurrent infections and bladder stones.

Cardiac Contraindications:

Hypotension, mechanical heart failure (valvular, pulmonary embolism, pericarditis), congestive heart failure.

Other contraindications:

Tamsulosin should be paused perioperatively for cataract surgery to prevent an intraoperative floppy iris syndrome.

Dosage of Tamsulosin

0.4 mg orally once daily.

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Chapple 2004 CHAPPLE, C. R.: Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician.
In: BJU Int
94 (2004), Nr. 5, S. 738–44

M. G. Lucas, T. P. Stephenson, and V. Nargund, “Tamsulosin in the management of patients in acute urinary retention from benign prostatic hyperplasia,” BJU Int, vol. 95, no. 3, pp. 354–7, 2005.

M. Oelke and Fran&Atilde, “Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial.,” Eur. Urol., vol. 61, no. 5, pp. 917–925, 2012.

  Deutsche Version: Tamsulosin