Alpha-Blocker (4/5): Tamsulosin
Review Literatur: (Chapple, 2004).
General Pharmacology of Tamsulosin
Please see section general pharmacology of alpha-blocker.
Mechanism of Action of Tamsulosin
Tamsulosin is a selective alpha1A-blocker with a long elimination half-life.
Indications for Tamsulosin
- Treatment of lower urinary tract symptoms due to benign prostatic hyperplasia
Pharmacokinetics of Tamsulosin
- Elimination half-life 12 h
- The OCAS-preparation (Oral Controlled Absorption System) allows a single daily dosing.
Tamsulosin: Mechanism of Action
Postsynaptic alpha1A-blockade leads to:
- Smooth muscle relaxation of the prostate, bladder neck and the urethra. Alpha-blocker improve the dynamic component of subvesical obstruction due to benign prostatic hyperplasia (BPH).
General Side Effects of Alpha-Blocker
- Hypotension, orthostatic syncope, reflex tachycardia
- Stuffy nose
- Retrograde ejaculation
- Dizziness, weakness
- Tamsulosin is a selective alpha1A-blocker with a favorable cardiovascular side effect rate
Contraindications of Tamsulosin
Conservative treatment of BPH is not indicated, if surgical treatment is imperative: chronic urinary retention with renal failure, recurrent hematuria due to prostatic enlargement, recurrent infections and bladder stones.
Hypotension, mechanical heart failure (valvular, pulmonary embolism, pericarditis), congestive heart failure.
Tamsulosin should be paused perioperatively for cataract surgery to prevent an intraoperative floppy iris syndrome.
Dosage of Tamsulosin
0.4 mg 1–0–0
Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Chapple 2004 CHAPPLE, C. R.:
- Pharmacological therapy of benign prostatic hyperplasia/lower urinary
tract symptoms: an overview for the practising clinician.
In: BJU Int
94 (2004), Nr. 5, S. 738–44