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Definition of the Ask-Upmark Kidney
The Ask-Upmark kidney is a segmental hypoplasia of the kidney, which is most often caused by vesicoureteral reflux (VUR).
EtiologyThe Ask-Upmark kidney is the result of vesicoureteral reflux, since vesicoureteral reflux and chronic pyelonephritis are almost always detectable. Dysplasia of the renal parenchyma is also associated.
Segmental hypoplasia with scarring of the renal parenchyma leads to renin release, secondary hyperaldosteronism and arterial hypertension.
Signs and Symptoms of the Ask-Upmark Kidney
- Severe arterial hypertension
- Onset around the 10th year of life
- Hypertensive retinopathy
- Patients with bilateral manifestation are at risk for end stage renal failure.
Treatment of Ask-Upmark Kidney
The unilateral Ask-Upmark kidney with severe hypertension can be treated with nephrectomy.For bilateral disease, medical treatment of arterial hypertension and renal insufficiency is crucial.
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Deutsche Version: Ask-Upmark Niere