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Ask-Upmark Kidney: Etiology and Symptoms

Definition of the Ask-Upmark Kidney

The Ask-Upmark kidney is a segmental hypoplasia of the kidney often caused by vesicoureteral reflux (VUR).

Pathogenesis

The Ask-Upmark kidney is the result of vesicoureteral reflux and chronic pyelonephritis. Segmental hypoplasia with scarring of the renal parenchyma leads to renin release, secondary hyperaldosteronism and arterial hypertension.

Signs and Symptoms of the Ask-Upmark Kidney

Severe arterial hypertension
Onset around the 10th year of life
Hypertensive retinopathy
Patients with bilateral manifestation are at risk for end-stage renal failure.

Treatment of Ask-Upmark Kidney

Unilateral Ask-Upmark kidney with severe hypertension is treated with nephrectomy. Medical treatment of arterial hypertension and chronic kidney disease is crucial for bilateral disease.

Oligomeganephronia

Index

Kidney diseases

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

References

E. Harnisch, T. Leertouwer, K. Cransberg, and J. E. Kist-van Holthe, “A 3-year old girl with seizures, hypokalemia and metabolic alkalosis.,” BMJ case reports, vol. 2010, 2010.

Deutsche Version: Ask-Upmark Niere

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