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Ask-Upmark Kidney: Etiology, Symptoms and Treatment
Definition of the Ask-Upmark Kidney
The Ask-Upmark kidney is a segmental hypoplasia of the kidney that most often arises from vesicoureteral reflux (VUR).
Etiology of the Ask-Upmark Kidney
Given the associated chronic pyelonephritis and the almost invariably demonstrable VUR, Ask-Upmark kidney is considered a consequence of VUR. Dysplasia may also be present.
Pathogenesis
Segmental hypoplasia with scarring due to chronic pyelonephritis leads to renin release, secondary hyperaldosteronism, and arterial hypertension.
Signs and Symptoms of the Ask-Upmark Kidney
- Severe arterial hypertension
- Onset usually around the 10th year of life
- Hypertensive retinopathy
- Compensated renal insufficiency in bilateral disease
Treatment of Ask-Upmark Kidney
In bilateral disease, treat hypertension medically and manage renal insufficiency as it progresses. In unilateral Ask-Upmark kidney with treatment-refractory or clearly renin-mediated hypertension and low residual function, nephrectomy may normalize blood pressure.
| Oligomeganephronia | Index | Kidney diseases |
Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
References
E. Harnisch, T. Leertouwer, K. Cransberg, and J. E. Kist-van Holthe, “A 3-year old girl with seizures, hypokalemia and metabolic alkalosis.,” BMJ case reports, vol. 2010, 2010.
Deutsche Version: Ask-Upmark Niere
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