Dr. med. Dirk Manski

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Ofloxacin: Side Effects, Contraindications and Dosage

Review literature: (Simon und Stille, 1997).

Mechanism of Action of Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic, which interferes with the bacterial DNA synthesis via inhibition of the DNA gyrase or topoisomerase II. Fluoroquinolone antibiotics are bactericidal.

Indications for Ofloxacin

Ofloxacin is active against a variety of bacteria:

Urologic indications for ofloxacin are urinary tract infections, prostatitis, acute pyelonephritis, or epididymitis.

Pharmacokinetics of Ofloxacin

Side Effects of Ofloxacin

Interactions with Ofloxacin:

Do not give iron salts or magnesium or aluminum-containing antacids together with ofloxacin. Ofloxacin increases increases warfarin and glibenclamid effect.

Contraindications to Ofloxacin

Dosage of Ofloxacin

Normal dosage of ofloxacin is 200 mg 1-0-1 p.o. Reduced dosage in impaired renal or hepatic function to 100 mg 1-0-1 or 1-0-0. Treatment of uncomplicated gonorrhea with a single dose 400 mg p.o.






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References

Auquer u.a. 2002 AUQUER, F. ; CORDON, F. ; GORINA, E. ; CABALLERO, J. C. ; ADALID, C. ; BATLLE, J.: Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women.
In: Clin Microbiol Infect
8 (2002), Nr. 1, S. 50–4

Henry u.a. 2002 HENRY, Jr. ; BETTIS, R. B. ; RIFFER, E. ; HAVERSTOCK, D. C. ; KOWALSKY, S. F. ; MANNING, K. ; HAMED, K. A. ; CHURCH, D. A.: Comparison of once-daily extended-release ciprofloxacin and conventional twice-daily ciprofloxacin for the treatment of uncomplicated urinary tract infection in women.
In: Clin Ther
24 (2002), Nr. 12, S. 2088–104

Krcmery und Naber 1999 KRCMERY, S. ; NABER, K. G.: Ciprofloxacin once versus twice daily in the treatment of complicated urinary tract infections. German Ciprofloxacin UTI Study Group.
In: Int J Antimicrob Agents
11 (1999), Nr. 2, S. 133–8

Martin u.a. 1998 MARTIN, S. J. ; MEYER, J. M. ; CHUCK, S. K. ; JUNG, R. ; MESSICK, C. R. ; PENDLAND, S. L.: Levofloxacin and sparfloxacin: new quinolone antibiotics.
In: Ann Pharmacother
32 (1998), Nr. 3, S. 320–36

Mombelli u.a. 1999 MOMBELLI, G. ; PEZZOLI, R. ; PINOJA-LUTZ, G. ; MONOTTI, R. ; MARONE, C. ; FRANCIOLLI, M.: Oral vs. intravenous ciprofloxacin in the initial empirical management of severe pyelonephritis or complicated urinary tract infections: a prospective randomized clinical trial.
In: Arch Intern Med
159 (1999), Nr. 1, S. 53–8

Naber u.a. 1999 NABER, K. G. ; THEURETZBACHER, U. ; MONEVA-KOUCHEVA, G. ; STASS, H.: Urinary excretion and bactericidal activity of intravenous ciprofloxacin compared with oral ciprofloxacin.
In: Eur J Clin Microbiol Infect Dis
18 (1999), Nr. 11, S. 783–9

Raz u.a. 2000 RAZ, R. ; NABER, K. G. ; RAIZENBERG, C. ; ROHANA, Y. ; UNAMBA-OPARAH, I. ; KORFMAN, G. ; YANIV, I.: Ciprofloxacin 250 mg twice daily versus ofloxacin 200 mg twice daily in the treatment of complicated urinary tract infections in women.
In: Eur J Clin Microbiol Infect Dis
19 (2000), Nr. 5, S. 327–31

Reid u.a. 2000 REID, G. ; POTTER, P. ; DELANEY, G. ; HSIEH, J. ; NICOSIA, S. ; HAYES, K.: Ofloxacin for the treatment of urinary tract infections and biofilms in spinal cord injury.
In: Int J Antimicrob Agents
13 (2000), Nr. 4, S. 305–7

Simon und Stille 1997 SIMON, C. ; STILLE, W.: Antibiotika-Therapie in Klinik und Praxis.
9. Auflage.
Stuttgart New York : Schattauer, 1997

Talan u.a. 2004 TALAN, D. A. ; KLIMBERG, I. W. ; NICOLLE, L. E. ; SONG, J. ; KOWALSKY, S. F. ; CHURCH, D. A.: Once daily, extended release ciprofloxacin for complicated urinary tract infections and acute uncomplicated pyelonephritis.
In: J Urol
171 (2004), Nr. 2 Pt 1, S. 734–9

  Deutsche Version: Nebenwirkungen, Kontraindikationen und Dosierung von Ofloxacin