Dr. med. Dirk Manski

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Granuloma inguinale (Donovanosis): Symptoms and Treatment


Granuloma inguinale is a sexually transmitted disease with Calymmatobacterium granulomatis leading to progressive painless genital ulcers (CDC Guidelines, 2006) (Roest and van der Meijden, 2001) (Schneede et al., 2003).


Granuloma inguinale occurs mainly in tropical countries.


Pathogen of granuloma inguinale is gram-negative and intracellular Calymmatobacterium granulomatis.

Signs and Symptoms of Granuloma Inguinale

Incubation period around 50 days. Granuloma inguinale presents with progressive painless highly vascular genital ulcers without inguinal lymphadenopathy. The genital ulcers are destructive and can affect the genital organs, the groin and the perineal region.


The causative organism is difficult to culture. Granuloma inguinale is probable with a biopsy showing dark staining Donovan bodies. An attempt of culture should exclude Chancroid, which is the most important differential diagnosis.

Treatment of Granuloma Inguinale

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Center for Disease Control and Prevention.: Sexually transmitted diseases treatment guidelines 2006.
in: MMWR
2006; 55 (No. RR-11): 1–93.

Roest und van der Meijden 2001 ROEST, R. W. ; MEIJDEN, W. I. van der: European guideline for the management of tropical genito-ulcerative diseases.
12 Suppl 3 (2001), S. 78–83

Schneede u.a. 2003 SCHNEEDE, P. ; TENKE, P. ; HOFSTETTER, A. G.: Sexually transmitted diseases (STDs)-a synoptic overview for urologists.
In: Eur Urol
44 (2003), Nr. 1, S. 1–7

  Deutsche Version: Granuloma inguinae