Tadalafil for Erectile Dysfunction

PDE5 inhibitors (1/4): basic pharmacology, side effects, contraindications
PDE5 inhibitors (2/4): Sildenafil
PDE5 inhibitors (3/4): Tadalafil
PDE5 inhibitors (4/4): Vardenafil

Review Literature: (Hatzimouratidis and Hatzichristou, 2007).

Basic pharmacology, side effects, drug interactions and contraindications of tadalafil please see section PDE5 inhibitors.

Indications for Tadalafil

Tadalafil is used for the medical treatment of erectile dysfunction.

Pharmacokinetics of Tadalafil

Good Absorption of tadalafil after oral administration: the maximum effective concentrations is reached after 2 h. Tadalafil can be taken with food, the maximum effective concentration is not changed.
Degradation of tadalafil by hepatic cytochrome P450 (CYP3A4). Half-life 18 h. Excretion to 60% via the faeces.

Dosage of Tadalafil

In healthy men, the recommended starting dosage is 10 mg tadalafil. Depending on the effects and side effects, the dosage may then change to 20 mg tadalafil. In men with liver impairment, severe renal insufficiency, cardiac risk factors, in older men, with an antihypertensive medication or with cytochrome p450 inhibitors, the dosage should not be increased to 20 mg.

Sildenafil

Index

Vardenafil

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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References

Hatzimouratidis und Hatzichristou 2007 HATZIMOURATIDIS, Konstantinos ; HATZICHRISTOU, Dimitrios:: Phosphodiesterase type 5 inhibitors: the day after.
In: Eur Urol
51 (2007), Jan, Nr. 1, S. 75–88; discussion 89

Deutsche Version: Tadalafil

Last update

Dr. med. Dirk Manski
man...@urologielehrbuch.de