Sildenafil for Erectile Dysfunction
Review Literature: (Hatzimouratidis and Hatzichristou, 2007).
Basic pharmacology, side effects, drug interactions and contraindications of sildenafil please see section PDE5 inhibitors.
Indications for Sildenafil
Sildenafil is used for the medical treatment of erectile dysfunction.
Pharmacokinetics of Sildenafil
- Fast Absorption of sildenafil after oral administration: maximum effective concentrations 30–120 min after oral ingestion of sildenafil on an empty stomach. If sildenafil is taken with food, the maximum effective concentration is delayed and decreased.
- Degradation of sildenafil by hepatic cytochrome P450 (CYP3A4 and 2C9). Half-life 3–5 h. Excretion to 80% via the faeces.
Dosage of Sildenafil
In healthy men, the recommended starting dosage is 50 mg sildenafil. Depending on the effects and side effects, the dosage may then change to 25 mg or 100 mg sildenafil. In men with liver impairment, severe renal insufficiency, cardiac risk factors, in older men, with an antihypertensive medication or with cytochrome p450 inhibitors, the recommended starting dosage is 25 mg sildenafil.
Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Hatzimouratidis und Hatzichristou 2007 HATZIMOURATIDIS,
Konstantinos ; HATZICHRISTOU, Dimitrios:
- Phosphodiesterase type 5 inhibitors: the day after.
In: Eur Urol
51 (2007), Jan, Nr. 1, S. 75–88; discussion 89