Cystatin C – Serum Blood Test
The protease cystatin C is a protein with 120 amino acids, which is relatively constantly produced in nucleated body cells (housekeeping gene). The elimination is done exclusively by glomerular filtration.
0,53–0,95 mg/l, higher concentrations in children under the age of 1.
Laboratory test method:
Immunoturbidimetry: cystatin C and specific antibodies form antigen-antibody complexes which can be optically detected by a photometer (measurement of the resulting specific turbidity).
Early diagnosis of renal dysfunction, to estimate renal clearance without the need for urine collection.
Differential Diagnosis of Elevated Cystatin C
- Acute kidney injury and chronic renal insufficiency. Cystatin C is more sensitive than creatinine to detect mild kidney damage (40–80 ml/min GFR).
- The concentration of cystatin C is independent of age, weight, muscle mass and diet.
- Non-renal causes of cystatin C elevation are autoimmune diseases.
Calculation of the Glomerular Filtration Rate (GRF)
The following formula can estimate the glomerular filtration rate with the serum concentration of cystatin C (Larsson u.a., 2004):
GFR = 77,24 × (Cystatin C in mg/l)−1,26
Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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- Guder, W. G. & Nolte, J.
- Das Laborbuch für
Klinik und Praxis
Urban + Fischer, 2009
- Larsson, A.; Malm, J.; Grubb, A. & Hansson, L. O.
- Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C
values in mg/L.
Scand J Clin Lab Invest, 2004, 64,
Siegenthaler 1988 SIEGENTHALER, W. ;
SIEGENTHALER, W. (Hrsg.):
- Differentialdiagnose innerer Krankheiten.
Georg Thieme Verlag, Stuttgart, New York., 1988