Dr. med. Dirk Manski



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Bicalutamide: Hormonal Treatment of Advanced Prostate Cancer

Indications for Bicalutamide

Anti-androgen hormone treatment of prostate cancer with bicalutamide is a therapeutic option against prostate cancer in the following situations:

Furthermore, biculatamide is used to prevent erections after penile surgery with incision of the corpora cavernosa (off-label use).

Mechanism of Action of Bicalutamide

Bicalutamide is a nonsteroidal anti-androgen drug, which shows competitive antagonism in relation to the androgen receptor.

Pharmacokinetics of Bicalutamide

Side Effects of Bicalutamide

Interactions with Bicalutamide

Warfarin (displacement from the plasma protein binding), terfenadine or cisapride (inhibition of cytochromes).

Contraindications for Bicalutamide

Increased liver enzymes warrant dose reduction and regular laboratory monitoring. Bicalutamide should be stopped in progressive elevation of liver transaminases without evidence of liver metastases. Further contraindications are allergy, bicalutamide has no indications in women and children.

Dosage of Bicalutamide

In Germany, two dosages of bicalutamide are approved: 50 mg p.o. 1-0-0 or 150 mg 1-0-0 p.o:

150 mg/d bicalutamide is recommended for antiandrogenic monotherapy (as an alternative to treatment with GnRH agonists).

50 mg bicalutamide 1-0-0 p.o. is sufficient to prevent the testosterone flare at the beginning of GnRH agonist therapy or in combination with GnRH agonist treatment (maximal androgen blockade, MAB).







Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



References

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Loblaw u.a. 2004 LOBLAW, D. A. ; MENDELSON, D. S. ; TALCOTT, J. A. ; VIRGO, K. S. ; SOMERFIELD, M. R. ; BEN-JOSEF, E. ; MIDDLETON, R. ; PORTERFIELD, H. ; SHARP, S. A. ; SMITH, T. J. ; TAPLIN, M. E. ; VOGELZANG, N. J. ; WADE, Jr. ; BENNETT, C. L. ; SCHER, H. I.:
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Sieber u.a. 2004 SIEBER, P. R. ; KEILLER, D. L. ; KAHNOSKI, R. J. ; GALLO, J. ; MCFADDEN, S.:
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Smith u.a. 2004b SMITH, M. R. ; GOODE, M. ; ZIETMAN, A. L. ; MCGOVERN, F. J. ; LEE, H. ; FINKELSTEIN, J. S.:
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