Bilateral Anorchia: Vanishing Testis Syndrome
Definition of the Vanishing Testis Syndrome
Bilateral anorchia or the vanishing testis syndrome is a loss of testicular function during fetal development. It leads, depending on the time of the damage, to more or less pronounced male pseudohermaphroditism. The maximum variation is the loss of testicular function before the 8th week of fetal development, with female differentiation of the internal and external sex organs. The minimal variation is the male newborns with normal genitalia, but without detectable testicular function (after HCG stimulation).
Diagnosis of the Vanishing Testis Syndrome
The determination of the testosterone concentration before and after HCG stimulation does not show an adequate increase. Determination of Anti-Müllerian hormone (low) and inhibin (low). Diagnostic laparoscopy confirms the absence of testicular tissue (McEachern, 2004).
Treatment of Bilateral Anorchia
Normally, the patient is assigned to the male gender role with lifelong testosterone replacement treatment.
Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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- McEachern, R.; Houle, A.; Garel, L. & Vliet, G. V.
- Lost and found testes: the importance of the hCG stimulation test and other testicular markers to confirm a surgical declaration of anorchia.
Horm Res, 2004, 62, 124-128