Dr. med. Dirk Manski

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Verrucous Carcinoma of the Penis


Verrucous penile carcinoma (Buschke-Löwenstein tumor) is a variant of well-differentiated penile carcinoma with local aggressive exophytic papillary lesions.


Verrucous penile carcinoma is a rare disease.


Lichen sclerosus, balanitis, and phimosis are risk factors; see section penile cancer. Although verrucous carcinoma of the penis has macroscopic similarities with condylomata acuminata, the pathogenesis of verrucous carcinoma of the penis is not associated with HPV.


Verrucous carcinoma consists of well-differentiated squamous epithelium without significant cellular atypia or invasion of subepithelial connective tissue (pTa penile carcinoma). Lymph node metastases are seldom possible; this argues for de-differentiation to classic penile carcinoma.

Signs and symptoms:

Cauliflower-like penile tumor, which may displace and destroy local structures by compression [fig. Verrucous carcinoma of the penis].

Diagnosis and Treatment:

Perform an organ-preserving complete excision of the tumor with a minimal surgical margin if verrucous penile carcinoma is anticipated. Abundant and deep biopsies are necessary to differentiate from invasive penile carcinoma. Close follow-up is required. Invasive lymph node staging is necessary for those with persisting inguinal lymphadenopathy.

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


O.W. Hakenberg and E. Compérat and S. Minhas and A. Necchi and C. Protzel and N. Watkin, “EAU Guidelines: Penile Cancer,” 2020. [Online]. Available: https://uroweb.org/guidelines/penile-cancer/.

D. I. Jo, S. H. Han, S. H. Kim, H. Y. Kim, H. Chung, and H. S. Kim, “Optimal treatment for penile verrucous carcinoma: a systematic literature review.,” BMC Urol., vol. 21, no. 1, p. 13, 2021.

Seixas u.a. 1994 SEIXAS, A. L. ; ORNELLAS, A. A. ; MAROTA, A. ; WISNESCKY, A. ; CAMPOS, F. ; MORAES, J. R. de: Verrucous carcinoma of the penis: retrospective analysis of 32 cases.
In: J Urol
152 (1994), Nr. 5 Pt 1, S. 1476–8; discussion 1478–9

  Deutsche Version: Verruköses Peniskarzinom