Urology-Textbook.com

Up-to-date urology insights from Dirk Manski

 You are here: Urology Textbook > Penis > Verrucous carcinoma

Verrucous Carcinoma of the Penis

Buschke-Löwenstein tumor: verrucous penile carcimone presenting as a cauliflower-like tumor. Image by William R. Smart, San Rafael, California, Public Health Image Library, Center for Disease Control and Prevention, USA, https://phil.cdc.gov/
Do you want to see the illustration? Please support this website with a Steady membership. In return, you will get access to all images and eliminate the advertisements. Please note: some medical illustrations in urology can be disturbing, shocking, or disgusting for non-specialists. Click here for more information.

Definition:

Verrucous penile carcinoma (Buschke-Löwenstein tumor) is a variant of well-differentiated penile carcinoma with local aggressive exophytic papillary lesions.

Epidemiology:

Verrucous penile carcinoma is a rare disease.

Etiology:

Lichen sclerosus, balanitis, and phimosis are risk factors; see section penile cancer. Although verrucous carcinoma of the penis has macroscopic similarities with condylomata acuminata, the pathogenesis of verrucous carcinoma of the penis is not associated with HPV.

Pathology:

Verrucous carcinoma consists of well-differentiated squamous epithelium without significant cellular atypia or invasion of subepithelial connective tissue (pTa penile carcinoma). Lymph node metastases are seldom possible; this argues for de-differentiation to classic penile carcinoma.

Signs and symptoms:

Cauliflower-like penile tumor, which may displace and destroy local structures by compression [fig. Verrucous carcinoma of the penis].

Diagnosis and Treatment:

Perform an organ-preserving complete excision of the tumor with a minimal surgical margin if verrucous penile carcinoma is anticipated. Abundant and deep biopsies are necessary to differentiate from invasive penile carcinoma. Close follow-up is required. Invasive lymph node staging is necessary for those with persisting inguinal lymphadenopathy.






Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

References

O.W. Hakenberg and E. Compérat and S. Minhas and A. Necchi and C. Protzel and N. Watkin, “EAU Guidelines: Penile Cancer,” 2020. [Online]. Available: https://uroweb.org/guidelines/penile-cancer/.

D. I. Jo, S. H. Han, S. H. Kim, H. Y. Kim, H. Chung, and H. S. Kim, “Optimal treatment for penile verrucous carcinoma: a systematic literature review.,” BMC Urol., vol. 21, no. 1, p. 13, 2021.

Seixas u.a. 1994 SEIXAS, A. L. ; ORNELLAS, A. A. ; MAROTA, A. ; WISNESCKY, A. ; CAMPOS, F. ; MORAES, J. R. de: Verrucous carcinoma of the penis: retrospective analysis of 32 cases.
In: J Urol
152 (1994), Nr. 5 Pt 1, S. 1476–8; discussion 1478–9



  Deutsche Version: Verruköses Peniskarzinom

Urology-Textbook.com – Choose the Ad-Free, Professional Resource

This website is designed for physicians and medical professionals. It presents diseases of the genital organs through detailed text and images. Some content may not be suitable for children or sensitive readers. Many illustrations are available exclusively to Steady members. Are you a physician and interested in supporting this project? Join Steady to unlock full access to all images and enjoy an ad-free experience. Try it free for 7 days—no obligation.

-->