Urology-Textbook.com

Up-to-date urology insights from Dirk Manski

 You are here: Urology Textbook > Testes > Sertoli-cell tumor

Sertoli-Cell Tumor of the Testis

Definition

The Sertoli-cell tumor is a rare stromal tumor of the testis with the proliferation of Sertoli cells and the possibility of hormone production (Loy and Linke, 2003).

Epidemiology

1% of all testicular tumors, they occur in 30% before puberty.

Pathology of the Sertoli-cell Tumor

Sertoli-cell tumor are usually small, yellow-brown, and sharply circumscribed in the testicular tissue. There is a variable predominance of epithelial-like (Sertoli cells) or stromal-like proliferation. The histological criteria for malignancy, which occurs in 10% of cases, are poorly defined.

Signs and Symptoms

Diagnostic Workup

Laboratory tests

Laboratory tests:

For differential diagnosis of gynecomastia: Testosterone estrogen, LH, FSH, and prolactin. Tumor markers of germ cell tumors (AFP, HCG, and LDH) are within the normal range.

Ultrasound of the testes:

Testicular ultrasound imaging shows a well-circumscribed hypoechoic testicular mass; calcifications may be visible.

Staging:

If malignancy is possible, perform a CT scan of the chest and abdomen.

Treatment of Sertoli-cell Tumor

Surgical treatment

Inguinal radical orchiectomy is often the initial treatment for larger tumors. Testis-sparing surgery is possible for small tumors or if a benign tumor is suspected: after enucleation, the tumor is sent for a frozen section. If malignancy is suspected (germ cell tumor or malignant Sertoli-cell tumor), proceed with radical orchiectomy.

Retroperitoneal lymphadenectomy:

Offer (laparoscopic) retroperitoneal lymphadenectomy if pathology shows clear signs of malignancy or if enlarged retroperitoneal lymph nodes are present.

Chemotherapy:

Chemotherapy for metastatic Sertoli-cell tumors; however, the response rates are low with cisplatin-containing combination regimens.






Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

References

Loy und Linke 2003 LOY, V. ; LINKE, J.: [Endocrine tumors of the testis].
In: Pathologe
24 (2003), Nr. 4, S. 308–13



  Deutsche Version: Sertoli-Zell Tumor des Hodens

Urology-Textbook.com – Choose the Ad-Free, Professional Resource

This website is designed for physicians and medical professionals. It presents diseases of the genital organs through detailed text and images. Some content may not be suitable for children or sensitive readers. Many illustrations are available exclusively to Steady members. Are you a physician and interested in supporting this project? Join Steady to unlock full access to all images and enjoy an ad-free experience. Try it free for 7 days—no obligation.

-->