Vardenafil for Erectile Dysfunction
- PDE5 inhibitors (1/4): basic pharmacology, side effects, contraindications
- PDE5 inhibitors (2/4): Sildenafil
- PDE5 inhibitors (3/4): Tadalafil
- PDE5 inhibitors (4/4): Vardenafil
Review Literature: (Hatzimouratidis and Hatzichristou, 2007).
Basic pharmacology, side effects, drug interactions and contraindications of vardenafil please see section PDE5 inhibitors.
Indications for Vardenafil
Vardenafil is used for the medical treatment of erectile dysfunction.
Pharmacokinetics of Vardenafil
- Fast Absorption of vardenafil after oral administration: maximum effective concentrations 30–120 min after oral ingestion of vardenafil on an empty stomach. If vardenafil is taken with food, the maximum effective concentration is delayed and decreased.
- Degradation of vardenafil by hepatic cytochrome P450 (CYP3A4). Half-life 4–5 h. Excretion to 90% via the faeces.
Dosage of Vardenafil
In healthy men, the recommended starting dosage is 10 mg vardenafil. Depending on the effects and side effects, the dosage may then change to 5 mg or 20 mg vardenafil. In men with liver impairment, severe renal insufficiency, cardiac risk factors, in older men, with an antihypertensive medication or with cytochrome p450 inhibitors, the starting dosage should be 5 mg.
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References
- Hatzimouratidis und Hatzichristou 2007 HATZIMOURATIDIS, Konstantinos ; HATZICHRISTOU, Dimitrios:
- Phosphodiesterase type 5 inhibitors: the day after.
In: Eur Urol
51 (2007), Jan, Nr. 1, S. 75–88; discussion 89
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Dr. med. Dirk Manski
man...@urologielehrbuch.de