Dr. med. Dirk Manski



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Trospium Chloride: Treatment of Overactive Bladder

Trospium chloride is a quaternary amine with anticholinergic properties, there is a high affinity for M1 and M3 muscarinic receptors. Trospium chloride is used to treat enuresis, urge incontinence and neurogenic bladder dysfunction. Review literature: (Ouslander, 2004) (Yoshimura and Chancellor, 2002).

For mechanism of action, side effects, contraindications and interactions of anticholinergics see section anticholinergics.

Pharmacokinetics of Trospium Chloride:

Trospium chloride is a quaternary amine, it has a very low penetrance of the blood-brain barrier and thus cerebral side effects are not as prominent. Half live 5–20 h. Elimination: mainly unchanged renal excretion.

Dosage of Trospium Chloride:

5 mg 1-1-1 to 15 mg 1-1-1. 20 mg is the maximum daily dosage of trospium chloride in patients with renal clearance below 30 ml/min.

Brand Names of Trospium Chloride

Sanctura, Tropez OD, Trosec, Regurin, Flotros, Spasmex, Spasmolyt.







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References for Trospium

Ouslander 2004 OUSLANDER, J. G.:
Management of overactive bladder.
In: N Engl J Med
350 (2004), Nr. 8, S. 786–99

Yoshimura und Chancellor 2002 YOSHIMURA, N. ; CHANCELLOR, M. B.:
Current and future pharmacological treatment for overactive bladder.
In: J Urol
168 (2002), Nr. 5, S. 1897–913


  Deutsche Version: Trospium Chlorid