Dr. med. Dirk Manski



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Prostate Cancer Treatment Options


Guidelines and review literature: (EAU Guidelines, Mottet et al, 2015) (S3-Leitlinie Prostatakarzinom der DGU) (Walsh-Campbell Urology 11th Edition).

Treatment Algorithm for Prostate Cancer Depending On Clinical Risk and Life Expectancy

For the clinical risk stratification see table D'Amico risk stratification of prostate cancer.

Organ Limited Prostate Cancer:

Low Risk Prostate Cancer (PSA <10 ng/ml and Gleason Score ≤6):

The cancer-specific mortality is low within 10–15 years, a curative treatment is indicated for patients with a life expectancy of over 15 years. Randomized trials did not show a significant differences between observation and radical prostatectomy after 10 years (Wilt et al, 2012).

Life Expectancy Over 10 Years:

Active surveillance is a treatment option in patients who wish deferred therapy to avoid side effects. If treatment is desired or if patients progress under active surveillance, patients can choose between radical prostatectomy, external beam radiation therapy or brachytherapy.

Life Expectancy Below 10 Years:

Active surveillance is the therapy of choice. If patients progress under active surveillance, curative radiation therapy or radical prostatectomy are possible. As an alternative to active treatment with immediate side effects, watchful waiting for metastatic disease and start of hormone therapy is also an option.

Intermediate and High Risk Prostate Cancer (PSA > 10 ng/ml or Gleason Score ≥7):

There is a relevant risk within 10 years to progress to metastatic disease or to die from prostate cancer within 15 years. Curative treatment is necessary for patients with a life expectancy of 5–10 years necessary (depending on the co-morbidities).

Life expectancy Over 10 years:

Radical prostatectomy is treatment of choice. Patients with R1 resection may need adjuvant radiotherapy, patients with lymph node metastases may need adjuvant hormonal therapy. As an alternative, curative radiotherapy with adjuvant hormonal therapy is an option. For poorly differentiated tumors, radical prostatectomy has better results in retrospective comparative series than radiotherapy.

Life Expectancy Below 10 Years:

Curative radiotherapy with adjuvant hormone therapy is treatment of choice. For patients with subvesical obstruction, radical prostatectomy should be preferred.

Life Expectancy Below 5 Years:

TURP for patients with subvesical obstruction. A curative therapy is not necessary, an antiandrogenic therapy is not indicated without the presence of metastases.

Metastatic Prostate Cancer:

Antiandrogen therapy is treatment of choice. For patients with a high tumor burden, Chemotherapy with docetaxel should be considered in addition to hormone therapy. If patients progress under hormone therapy, numerous further treatment options are available. Important is the palliation of symptoms with pain therapy, bisphosphonates, denosumab and radiotherapy of painful bone metastases.







Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z





References

N. Mottet (Chair), J. Bellmunt, E. Briers (Patient Representative), R.C.N. van den Bergh (Guidelines Associate), M. Bolla, N.J. van Casteren (Guidelines Associate), P. Cornford, S. Culine, S. Joniau, T. Lam, M.D. Mason, V. Matveev, H. van der Poel, T.H. van der Kwast, O. Rouvière, T. Wiegel
Guidelines on Prostate Cancer of the European Association of Urology (EAU), https://uroweb.org/guideline/prostate-cancer/.


Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF):
Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschiedenen Stadien des Prostatakarzinoms, Langversion 3.1, 2014 AWMF Registernummer: 034/022OL, http://www.awmf.org/leitlinien/detail/ll/043-022OL.html (Zugriff am: 07.02.2016)


Wein, A. J.; Kavoussi, L. R.; Partin, A. P. & Peters, C. A.
Campbell-Walsh Urology
. Elsevier, 2015. ISBN 978-1455775675.


Wilt, T. J.; Brawer, M. K.; Jones, K. M.; Barry, M. J.; Aronson, W. J.; Fox, S.; Gingrich, J. R.; Wei, J. T.; Gilhooly, P.; Grob, B. M.; Nsouli, I.; Iyer, P.; Cartagena, R.; Snider, G.; Roehrborn, C.; Sharifi, R.; Blank, W.; Pandya, P.; Andriole, G. L.; Culkin, D.; Wheeler, T. & PIVOT Study Group
Radical prostatectomy versus observation for localized prostate cancer.
2012, 367, 203-213.


  Deutsche Version: Prostatakarzinom