Dr. med. Dirk Manski

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Granuloma inguinale (Donovanosis)

Review literature: (CDC Guidelines, 2006) (Roest and van der Meijden, 2001) (Schneede et al, 2003).


Sexually transmitted disease with Calymmatobacterium granulomatis leading to progressive painless genital ulcers


Granuloma inguinale occurs mainly in tropical countries.


Pathogen of granuloma inguinale is gram-negative and intracellular Calymmatobacterium granulomatis.

Signs and Symptoms

Granuloma inguinale presents with progressive painless genital ulcers without inguinal lymphadenopathy. The genital ulcers are destructive and can affect the genital organs, the groin and the perineal region. The lesions are highly vascular ("beefy red" appearance) and bleed easily on contact.


The causative organism is difficult to culture. Granuloma inguinale is probable with a biopsy showing dark staining Donovan bodies. An attempt of culture should exclude Chancroid, which is the most important differential diagnosis.

Treatment of Granuloma Inguinale

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


Center for Disease Control and Prevention.:
Sexually transmitted diseases treatment guidelines 2006.
in: MMWR
2006; 55 (No. RR-11): 1–93.

Roest und van der Meijden 2001 ROEST, R. W. ; MEIJDEN, W. I. van der:
European guideline for the management of tropical genito-ulcerative diseases.
12 Suppl 3 (2001), S. 78–83

Schneede u.a. 2003 SCHNEEDE, P. ; TENKE, P. ; HOFSTETTER, A. G.:
Sexually transmitted diseases (STDs)-a synoptic overview for urologists.
In: Eur Urol
44 (2003), Nr. 1, S. 1–7

  Deutsche Version: Granuloma inguinae