Dr. med. Dirk Manski



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Flutamide: Anti-Androgen Prostate Cancer Hormone Treatment

Indications for Flutamide

Anti-androgen hormone treatment of prostate cancer with flutamide is a therapeutic option against prostate cancer in the following situations:

Furthermore, flutamide is used to prevent erections after penile surgery with incision of the corpora cavernosa (off-label use).

Mechanism of Action of Flutamide

Flutamide is a nonsteroidal anti-androgen drug which binds without biological activity to the androgen receptor (competitive antagonism).

Pharmacokinetics of Flutamide

Side Effects of Flutamide

Contraindications for Flutamide

Liver insufficiency. Increased liver enzymes during flutamide treatment warrant dose reduction and regular laboratory monitoring. Flutamide should be stopped in progressive elevation of liver transaminases without evidence of liver metastases. Further contraindications are allergy, flutamide has no indications in women and children.

Dosage of Flutamide

200 mg 1-1-1 p.o.







Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



References

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Diamond u.a. 2004 DIAMOND, T. H. ; HIGANO, C. S. ; SMITH, M. R. ; GUISE, T. A. ; SINGER, F. R.:
Osteoporosis in men with prostate carcinoma receiving androgen-deprivation therapy: recommendations for diagnosis and therapies.
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Fradet u.a. 2007 FRADET, Yves ; EGERDIE, Blair ; ANDERSEN, Morten ; TAMMELA, Teuvo L J. ; NACHABE, Mahmoud ; ARMSTRONG, Jon ; MORRIS, Thomas ; NAVANI, Sunil:
Tamoxifen as prophylaxis for prevention of gynaecomastia and breast pain associated with bicalutamide 150 mg monotherapy in patients with prostate cancer: a randomised, placebo-controlled, dose-response study.
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Loblaw u.a. 2004 LOBLAW, D. A. ; MENDELSON, D. S. ; TALCOTT, J. A. ; VIRGO, K. S. ; SOMERFIELD, M. R. ; BEN-JOSEF, E. ; MIDDLETON, R. ; PORTERFIELD, H. ; SHARP, S. A. ; SMITH, T. J. ; TAPLIN, M. E. ; VOGELZANG, N. J. ; WADE, Jr. ; BENNETT, C. L. ; SCHER, H. I.:
American Society of Clinical Oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer.
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Miyamoto u.a. 2004 MIYAMOTO, H. ; MESSING, E. M. ; CHANG, C.:
Androgen deprivation therapy for prostate cancer: current status and future prospects.
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Perdona u.a. 2005 PERDONA, S. ; AUTORINO, R. ; DPLACIDO, S. ; D’ARMIENTO, M. ; GALLO, A. ; DAMIANO, R. ; PINGITORE, D. ; GALLO, L. ; DSIO, M. ; BIANCO, A. R. ; DLORENZO, G.:
Efficacy of tamoxifen and radiotherapy for prevention and treatment of gynaecomastia and breast pain caused by bicalutamide in prostate cancer: a randomised controlled trial.
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Sieber u.a. 2004 SIEBER, P. R. ; KEILLER, D. L. ; KAHNOSKI, R. J. ; GALLO, J. ; MCFADDEN, S.:
Flutamide 150 mg maintains bone mineral density during monotherapy for localized or locally advanced prostate cancer.
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Smith u.a. 2004b SMITH, M. R. ; GOODE, M. ; ZIETMAN, A. L. ; MCGOVERN, F. J. ; LEE, H. ; FINKELSTEIN, J. S.:
Bicalutamide monotherapy versus leuprolide monotherapy for prostate cancer: effects on bone mineral density and body composition.
In: J Clin Oncol
22 (2004), Nr. 13, S. 2546–53.

Tyrrell u.a. 2004 TYRRELL, C. J. ; PAYNE, H. ; TAMMELA, T. L. ; BAKKE, A. ; LODDING, P. ; GOEDHALS, L. ; VAN ERPS, P. ; BOON, T. ; VAN DBEEK, C. ; ANDERSSON, S. O. ; MORRIS, T. ; CARROLL, K.:
Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia.
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60 (2004), Nr. 2, S. 476–83.

Widmark u.a. 2003 WIDMARK, A. ; FOSSA, S. D. ; LUNDMO, P. ; DAMBER, J. E. ; VAAGE, S. ; DAMBER, L. ; WIKLUND, F. ; KLEPP, O.:
Does prophylactic breast irradiation prevent antiandrogen-induced gynecomastia? Evaluation of 253 patients in the randomized Scandinavian trial SPCG-7/SFUO-3.
In: Urology
61 (2003), Nr. 1, S. 145–51.


  Deutsche Version: Bicalutamid