Dr. med. Dirk Manski



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Alpha-blocker (5/6): Alfuzosin

Review Literatur: (Chapple, 2004).

General Pharmacology of Alfuzosin

Please see section general pharmacology of alpha-blocker.

Mechanism of Action of Alfuzosin

Alfuzosin is a alpha1-blocker.

Indications for Alfuzosin

Pharmacokinetics of Alfuzosin

Alfuzosin: Mechanism of Action

Postsynaptic alpha1-blockade leads to:

General Side Effects of Alpha-Blocker

Contraindications of Alfuzosin

Urological Contraindications:

Conservative treatment of BPH is not indicated, if surgical treatment is imperative: chronic urinary retention with renal failure, recurrent hematuria due to prostatic enlargement, recurrent infections and bladder stones.

Cardiac Contraindications:

Hypotension, mechanical heart failure (valvular, pulmonary embolism, pericarditis), congestive heart failure.

Other contraindications:

Alfuzosin should be paused perioperatively for cataract surgery to prevent an intraoperative floppy iris syndrome.

Dosage of Alfuzosin

10 mg in retarded galenic formulation 1–0–0 or 2.5 mg 1–1–1 or 5 mg 1–1–1







Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



References

Chapple 2004 CHAPPLE, C. R.:
Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician.
In: BJU Int
94 (2004), Nr. 5, S. 738–44


  Deutsche Version: Alfuzosin